A game change in biosensing
Cell-free synthetic biology for combinatorial biosensor design
Synthetic biology is a key technology of the 21st century and is fuelling a new wave of innovations with significant impact on economies and societies. Cell-free synthetic biology and its use in biosensor design will be transformative for domains ranging from in-vitro diagnostics to health, environmental and bioprocess monitoring, yielding fast and cost-efficient sensors with unprecedented sensitivity and specificity.
Cell-free synthetic biology
Cell-free biological systems make use of the transcriptional and translational machinery by using extracts or purified systems instead of living cells. This reduces the complexity of the system and enables better control of the processes to find standardised engineering solutions to new challenges.
Molecular sensor design
Molecular biosensors combine synthetic DNA-programmable responsive elements with transcription/translation systems to obtain a measurable signal (e.g. optical output) in the presence of a specific target analyte. To achieve programmable, intelligent biosensors that will respond to multi-dimensional analyte profiles, well-characterized regulatory elements combined with computer-aided design methods are needed.